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DANRE shha Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - DANRE shha Antibody (Center) Azb10041a
    Shha Antibody (Center) (Cat.# Azb10041a) western blot analysis in zebrafish brain tissue lysate (35ug/lane). This demonstrates that the (DANRE) shha antibody detected zebrafish shha protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q92008
Reactivity Zebrafish
Host Rabbit
Clonality Polyclonal
Clone Names RB46723
Calculated MW 46403 Da
Additional Information
Gene ID 30269
Other Names Sonic hedgehog protein A, SHHA, VHH-1, Sonic hedgehog protein A N-product, Sonic hedgehog protein A C-product, shha, shh, vhh1
Target/Specificity This shha antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 151-162 amino acids from the Central region of DANRE shha.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDANRE shha Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name shha
Synonyms shh, vhh1
Function Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning, dorso-ventral patterning of the brain and early patterning of the developing eyes. Displays floor plate-inducing activity. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO (By similarity).
Cellular Location Sonic hedgehog protein A C-product: Secreted, extracellular space. Note=The C-terminal peptide diffuses from the cell.
Tissue Location Expressed in the ventral midline of the neural tube and brain. Also found in the notochord and in developing fin bud. In the developing brain, expression occurs in domains that include a discrete region in the floor of the diencephalon
Research Areas
Citations (0)

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Background

Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning, dorso-ventral patterning of the brain and early patterning of the developing eyes. Displays floor plate-inducing activity. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO (By similarity).

References

Roelink H.,et al.Cell 76:761-775(1994).
Ekker S.C.,et al.Curr. Biol. 5:944-955(1995).
Fietz M.J.,et al.Development Suppl. 120:43-51(1994).
Muller F.,et al.Development 126:2103-2116(1999).
Zardoya R.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:13036-13041(1996).

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$ 295.00
$ 99.00
Cat# Azb10041a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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