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(DANRE) srebf2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - (DANRE) srebf2 Antibody (Center) Azb18706a
    Western blot analysis of lysates from Zebrafish and zebra fish muscle tissue lysate (from left to right), using (DANRE) srebf2 Antibody (Center)(Cat. #Azb18706a). Azb18706a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession A3KNA7
Reactivity Zebrafish
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Clone Names RB49773
Calculated MW 120321 Da
Additional Information
Gene ID 100037309
Other Names Sterol regulatory element-binding protein 2, SREBP-2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2, srebf2 {ECO:0000250|UniProtKB:Q12772}
Target/Specificity This (DANRE) srebf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 441-473 amino acids from the Central region of human (DANRE) srebf2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(DANRE) srebf2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name srebf2 {ECO:0000250|UniProtKB:Q12772}
Function Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity).
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q12772}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12772}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q12772}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12772}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q12772}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12772}. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols {ECO:0000250|UniProtKB:Q12772}
Research Areas
Citations (0)

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Background

Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity).

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$ 295.00
$ 99.00
Cat# Azb18706a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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