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C1orf84 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q5T011
Other Accession NP_001012979.1, NP_056099.2
Clone Names 91230316
Peptide ID 91230316
Additional Information
Gene ID 23334
Other Names Protein SZT2, Seizure threshold 2 protein homolog, SZT2, C1orf84, KIAA0467
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SZT2 (HGNC:29040)
Function As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity).
Cellular Location Lysosome membrane Peroxisome {ECO:0000250|UniProtKB:A2A9C3}. Note=Localization to lysosomes is amino acid-independent.
Tissue Location Expressed in the brain, predominantly in the parietal and frontal cortex, as well as in dorsal root ganglia Expressed in peripheral white blood cells
Research Areas
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$ 80.00
Cat# BP10026a
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