TESK1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q15569 |
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Other Accession | NP_006276.2 |
Clone Names | 100623332 |
Gene ID | 7016 |
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Other Names | Dual specificity testis-specific protein kinase 1, Testicular protein kinase 1, TESK1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TESK1 |
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Function | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin- mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). |
Cellular Location | Cytoplasm. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q63572} Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q63572}. Note=Colocalizes with SPRY4 in vesicular spots in the cytoplasm (PubMed:15584898). Localized to F- actin-rich lamellipodia at the cell periphery following fibronectin- mediated cell adhesion of Schwann cells (By similarity) {ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898} |
Tissue Location | Expressed in podocytes and renal tubular cells in the kidney (at protein level). |
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