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BCA3 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NQ31
Other Accession P50440, NP_001473.1, NP_878904.2, NP_065693.2
Clone Names 70319133
Peptide ID 70319133
Additional Information
Other Names A-kinase-interacting protein 1, Breast cancer-associated gene 3 protein, PKA-interacting protein, Proline-rich protein BCA3, AKIP1, BCA3, C11orf17
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKIP1
Synonyms BCA3, C11orf17
Function Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
Cellular Location Nucleus. Note=Locates to punctate spots
Tissue Location Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up- regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain. EMBL; AF493783; AAM12862.1; -; mRNA EMBL; AF493784; AAM12863.1; -; mRNA EMBL; AF493785; AAM12864.1; -; mRNA EMBL; AF493786; AAM12865.1; -; Genomic_DNA EMBL; AF493786; AAM12866.1; -; Genomic_DNA EMBL; AF493786; AAM12867.1; -; Genomic_DNA EMBL; AF512007; AAM34785.1; -; mRNA EMBL; AJ400877; CAB92290.1; -; Genomic_DNA EMBL; AK075308; BAC11537.1; -; mRNA EMBL; BC030996; AAH30996.1; -; mRNA CCDS; CCDS55743.1; -. [Q9NQ31-2] CCDS; CCDS55744.1; -. [Q9NQ31-3] CCDS; CCDS7793.1; -. [Q9NQ31-1] RefSeq; NP_001193575.1; NM_001206646.1. [Q9NQ31-3] RefSeq; NP_001193576.1; NM_001206647.1. [Q9NQ31-2] RefSeq; NP_001193577.1; NM_001206648.1 RefSeq; NP_065693.2; NM_020642.3. [Q9NQ31-1] RefSeq; XP_016873500.1; XM_017018011.1. [Q9NQ31-1] UniGene; Hs.131180; - ProteinModelPortal; Q9NQ31; - SMR; Q9NQ31; - BioGrid; 121180; 13 IntAct; Q9NQ31; 5 STRING; 9606.ENSP00000310459; - iPTMnet; Q9NQ31; - PhosphoSitePlus; Q9NQ31; - BioMuta; AKIP1; - MaxQB; Q9NQ31; - PaxDb; Q9NQ31; - PeptideAtlas; Q9NQ31; - PRIDE; Q9NQ31; - ProteomicsDB; 82063; - ProteomicsDB; 82064; -. [Q9NQ31-2] ProteomicsDB; 82065; -. [Q9NQ31-3] DNASU; 56672; - Ensembl; ENST00000299576; ENSP00000299576; ENSG00000166452. [Q9NQ31-3] Ensembl; ENST00000309357; ENSP00000310644; ENSG00000166452. [Q9NQ31-2] Ensembl; ENST00000309377; ENSP00000310459; ENSG00000166452. [Q9NQ31-1] Ensembl; ENST00000396648; ENSP00000379885; ENSG00000166452. [Q9NQ31-3] Ensembl; ENST00000534147; ENSP00000431331; ENSG00000166452. [Q9NQ31-1] GeneID; 56672; - KEGG; hsa:56672; - UCSC; uc001mgx.4; human. [Q9NQ31-1] CTD; 56672; - DisGeNET; 56672; - EuPathDB; HostDB:ENSG00000166452.11; - GeneCards; AKIP1; - H-InvDB; HIX0009428; - HGNC; HGNC:1170; AKIP1 HPA; HPA061391; - MIM; 609191; gene neXtProt; NX_Q9NQ31; - OpenTargets; ENSG00000166452; - PharmGKB; PA25484; - eggNOG; ENOG410IGJ9; Eukaryota eggNOG; ENOG41114P0; LUCA GeneTree; ENSGT00390000017064; - HOVERGEN; HBG030457; - InParanoid; Q9NQ31; - OMA; REERHPT; - OrthoDB; EOG091G0W3L; - PhylomeDB; Q9NQ31; - TreeFam; TF337318; - ChiTaRS; AKIP1; human GenomeRNAi; 56672; - PRO; PR:Q9NQ31; - Proteomes; UP000005640; Chromosome 11 Bgee; ENSG00000166452; - CleanEx; HS_C11orf17; - ExpressionAtlas; Q9NQ31; baseline and differential Genevisible; Q9NQ31; HS GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:1901222; P:regulation of NIK/NF-kappaB signaling; IEA:InterPro GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl InterPro; IPR033214; AKIP1 PANTHER; PTHR14330; PTHR14330; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Nucleus; Polymorphism; Proto-oncogene; Reference proteome CHAIN 1 210 A-kinase-interacting protein 1 /FTId=PRO_0000064857 VAR_SEQ 75 101 Missing (in isoform 3) /FTId=VSP_013275 VAR_SEQ 137 163 Missing (in isoform 2) /FTId=VSP_013276 VARIANT 23 23 R -> K (in dbSNP:rs1133833) /FTId=VAR_021565 VARIANT 132 132 I -> T (in dbSNP:rs35131475) /FTId=VAR_050688 CONFLICT 41 41 A -> T (in Ref. 4; BAC11537) CONFLICT 92 92 F -> S (in Ref. 4; BAC11537) SEQUENCE 210 AA; 23114 MW; F00AA1F166C37967 CRC64; MDNCLAAAAL NGVDRRSLQR SARLALEVLE RAKRRAVDWH ALERPKGCMG VLAREAPHLE KQPAAGPQRV LPGEREERPP TLSASFRTMA EFMDYTSSQC GKYYSSVPEE GGATHVYRYH RGESKLHMCL DIGNGQRKDR KKTSLGPGGS YQISEHAPEA SQPAENISKD LYIEVYPGTY SVTVGSNDLT KKTHVVAVDS GQSVDLVFPV
Research Areas
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References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gao, N., et al. J. Biol. Chem. 285(36):28097-28104(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Gao, N., et al. J. Biol. Chem. 283(12):7834-7843(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)

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