|Other Names||DNA replication licensing factor MCM5, CDC46 homolog, P1-CDC46, MCM5, CDC46|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.|
|Cellular Location||Nucleus. Cytoplasm, cytosol|
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The protein encoded by this gene is structurally verysimilar to the CDC46 protein from S. cerevisiae, a protein involvedin the initiation of DNA replication. The encoded protein is amember of the MCM family of chromatin-binding proteins and caninteract with at least two other members of this family. Theencoded protein is upregulated in the transition from the G0 toG1/S phase of the cell cycle and may actively participate in cellcycle regulation.
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Saade, E., et al. Proteomics 9(21):4934-4943(2009)Snyder, M., et al. J. Biol. Chem. 284(20):13466-13472(2009)Stalinska, L., et al. Histol. Histopathol. 24(3):299-308(2009)Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)
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