|Other Names||DNA replication licensing factor MCM5, CDC46 homolog, P1-CDC46, MCM5, CDC46|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is structurally verysimilar to the CDC46 protein from S. cerevisiae, a protein involvedin the initiation of DNA replication. The encoded protein is amember of the MCM family of chromatin-binding proteins and caninteract with at least two other members of this family. Theencoded protein is upregulated in the transition from the G0 toG1/S phase of the cell cycle and may actively participate in cellcycle regulation.
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Saade, E., et al. Proteomics 9(21):4934-4943(2009)Snyder, M., et al. J. Biol. Chem. 284(20):13466-13472(2009)Stalinska, L., et al. Histol. Histopathol. 24(3):299-308(2009)Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.