|Other Names||Adipocyte enhancer-binding protein 1, AE-binding protein 1, Aortic carboxypeptidase-like protein, AEBP1, ACLP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.|
|Cellular Location||Isoform 1: Secreted.|
|Tissue Location||Expressed in osteoblast and visceral fat.|
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The adipocyte enhancer binding protein 1 is atranscriptional repressor with carboxypeptidase (CP) activity. Thisprotein binds to a regulatory sequence, adipocyte enhancer 1(AE-1), located in the proximal promoter region of the adipose P2(aP2) gene, which encodes the adipocyte fatty-acid binding protein.It is characterized as a member of the regulatory B-like CP family.This protein seems to be activated by a novel mechanism, wherebythe direct binding of DNA enhances its protease activity.Adipocyte-enhancer binding protein 1 may play a role indifferentiated vascular smooth muscle cells.
Majdalawieh, A., et al. Nucl Recept Signal 8, E004 (2010) :Schissel, S.L., et al. Am. J. Pathol. 174(3):818-828(2009)Zhang, L., et al. Mol. Med. 11 (1-12), 39-47 (2005) :Layne, M.D., et al. Mol. Cell. Biol. 21(15):5256-5261(2001)Muise, A.M., et al. Biochem. J. 343 PT 2, 341-345 (1999) :
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