|Other Names||Multidrug resistance-associated protein 6, ATP-binding cassette sub-family C member 6, Anthracycline resistance-associated protein, Multi-specific organic anion transporter E, MOAT-E, ABCC6, ARA, MRP6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).|
|Cellular Location||Isoform 1: Basolateral cell membrane; Multi- pass membrane protein|
|Tissue Location||Expressed in kidney and liver. Very low expression in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of thesuperfamily of ATP-binding cassette (ABC) transporters. ABCproteins transport various molecules across extra- andintra-cellular membranes. ABC genes are divided into seven distinctsubfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). Theencoded protein, a member of the MRP subfamily, is involved inmulti-drug resistance. Mutations in this gene cause pseudoxanthomaelasticum. Alternatively spliced transcript variants that encodedifferent proteins have been described for this gene. [provided byRefSeq].
Zarbock, R., et al. Clin. Chim. Acta 411 (19-20), 1487-1490 (2010) :de Boussac, H., et al. J. Biol. Chem. 285(30):22800-22808(2010)Uitto, J., et al. J. Invest. Dermatol. 130(3):661-670(2010)Costrop, L.M., et al. J. Hum. Genet. 55(2):112-117(2010)Uitto, J. Trends Mol Med 11(8):341-343(2005)
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