|Other Names||A disintegrin and metalloproteinase with thrombospondin motifs 10, ADAM-TS 10, ADAM-TS10, ADAMTS-10, 3424-, ADAMTS10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Widely expressed in adult tissues.|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the ADAMTS (a disintegrin andmetalloproteinase domain with thrombospondin type-1 motifs) familyof zinc-dependent proteases. ADAMTS proteases are complex secretedenzymes containing a prometalloprotease domain of the reprolysintype attached to an ancillary domain with a highly conservedstructure that includes at least one thrombospondin type 1 repeat.They have been demonstrated to have important roles in connectivetissue organization, coagulation, inflammation, arthritis,angiogenesis and cell migration. The product of this gene plays amajor role in growth and in skin, lens, and heart development. Itis also a candidate gene for autosomal recessive Weill-Marchesanisyndrome.
Morales, J., et al. Am. J. Hum. Genet. 85(5):558-568(2009)Ben Yahia, S., et al. J. Hum. Genet. 54(9):550-553(2009)Kutz, W.E., et al. Hum. Mutat. 29(12):1425-1434(2008)Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Dagoneau, N., et al. Am. J. Hum. Genet. 75(5):801-806(2004)
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