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AMACR Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UHK6 |
|---|---|
| Other Accession | NP_976316.1 |
| Clone Names | 80821002 |
| Gene ID | 23600 |
|---|---|
| Other Names | Alpha-methylacyl-CoA racemase, 2-methylacyl-CoA racemase, AMACR |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AMACR |
|---|---|
| Function | Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:7649182, PubMed:10655068, PubMed:11060359). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2- (4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:7649182, PubMed:10655068, PubMed:11060359). |
| Cellular Location | Peroxisome. Mitochondrion |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a racemase. The encoded enzymeinterconverts pristanoyl-CoA and C27-bile acylCoAs between their(R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomersis necessary for degradation of these substrates by peroxisomalbeta-oxidation. Encoded proteins from this locus localize to bothmitochondria and peroxisomes. Mutations in this gene may beassociated with adult-onset sensorimotor neuropathy, pigmentaryretinopathy, and adrenomyeloneuropathy due to defects in bile acidsynthesis. Alternatively spliced transcript variants have beendescribed.
References
Murray, N.P., et al. Oncol. Rep. 24(3):687-692(2010)Sonwalkar, S.A., et al. Histopathology 56(7):900-907(2010)Lakis, S., et al. World J. Gastroenterol. 16(20):2476-2483(2010)Chen, W., et al. Mol. Biol. Rep. 36(3):423-430(2009)Mubiru, J.N., et al. Gene 327(1):89-98(2004)
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