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AR Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P10275
Other Accession NP_001011645.1, NP_000035.2
Clone Names 80722015
Additional Information
Gene ID 367
Other Names Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AR
Synonyms DHTR, NR3C4
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Cellular Location Nucleus. Cytoplasm Note=Detected at the promoter of target genes (PubMed:25091737) Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.
Tissue Location [Isoform 2]: Mainly expressed in heart and skeletal muscle.
Research Areas
Citations (0)
citation

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Background

The androgen receptor gene is more than 90 kb long andcodes for a protein that has 3 major functional domains: theN-terminal domain, DNA-binding domain, and androgen-binding domain.The protein functions as a steroid-hormone activated transcriptionfactor. Upon binding the hormone ligand, the receptor dissociatesfrom accessory proteins, translocates into the nucleus, dimerizes,and then stimulates transcription of androgen responsive genes.This gene contains 2 polymorphic trinucleotide repeat segments thatencode polyglutamine and polyglycine tracts in the N-terminaltransactivation domain of its protein. Expansion of thepolyglutamine tract causes spinal bulbar muscular atrophy (Kennedydisease). Mutations in this gene are also associated with completeandrogen insensitivity (CAIS). Two alternatively spliced variantsencoding distinct isoforms have been described. [provided byRefSeq].

References

Shu, S.K., et al. J. Biol. Chem. 285(43):33045-33053(2010)Nedelsky, N.B., et al. Neuron 67(6):936-952(2010)Panda, B., et al. Gynecol. Endocrinol. (2010) In press :Schneider, G., et al. Am J Geriatr Psychiatry (2010) In press :Guadalupe-Grau, A., et al. PLoS ONE 5 (7), E11529 (2010) :

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$ 277.78
Cat# BP10111c
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