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AR Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P10275
Other Accession NP_001011645.1, NP_000035.2
Clone Names 80722015
Peptide ID 80722015
Additional Information
Gene ID 367
Other Names Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AR
Synonyms DHTR, NR3C4
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Cellular Location Nucleus. Cytoplasm. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1
Tissue Location Isoform 2 is mainly expressed in heart and skeletal muscle.
Research Areas
Citations (0)

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The androgen receptor gene is more than 90 kb long andcodes for a protein that has 3 major functional domains: theN-terminal domain, DNA-binding domain, and androgen-binding domain.The protein functions as a steroid-hormone activated transcriptionfactor. Upon binding the hormone ligand, the receptor dissociatesfrom accessory proteins, translocates into the nucleus, dimerizes,and then stimulates transcription of androgen responsive genes.This gene contains 2 polymorphic trinucleotide repeat segments thatencode polyglutamine and polyglycine tracts in the N-terminaltransactivation domain of its protein. Expansion of thepolyglutamine tract causes spinal bulbar muscular atrophy (Kennedydisease). Mutations in this gene are also associated with completeandrogen insensitivity (CAIS). Two alternatively spliced variantsencoding distinct isoforms have been described. [provided byRefSeq].


Shu, S.K., et al. J. Biol. Chem. 285(43):33045-33053(2010)Nedelsky, N.B., et al. Neuron 67(6):936-952(2010)Panda, B., et al. Gynecol. Endocrinol. (2010) In press :Schneider, G., et al. Am J Geriatr Psychiatry (2010) In press :Guadalupe-Grau, A., et al. PLoS ONE 5 (7), E11529 (2010) :

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$ 80.00
Cat# BP10111c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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