|Other Names||Apoptosis-enhancing nuclease, 31--, Interferon-stimulated 20 kDa exonuclease-like 1, AEN, ISG20L1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.|
|Cellular Location||Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction|
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Provided below are standard protocols that you may find useful for product applications.
Eby, K.G., et al. Mol. Cancer 9, 95 (2010) :Kawase, T., et al. Oncogene 27(27):3797-3810(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Lee, J.H., et al. Biochem. Biophys. Res. Commun. 337(1):39-47(2005)
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