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A4GALT Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NPC4
Other Accession NP_059132.1
Clone Names 81006001
Additional Information
Gene ID 53947
Other Names Lactosylceramide 4-alpha-galactosyltransferase, Alpha-1, 4-N-acetylglucosaminyltransferase, Alpha-1, 4-galactosyltransferase, Alpha4Gal-T1, CD77 synthase, Globotriaosylceramide synthase, Gb3 synthase, P1/Pk synthase, UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase, A4GALT, A14GALT, A4GALT1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name A4GALT
Synonyms A14GALT, A4GALT1
Function Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)) (PubMed:10748143). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143). Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P (PubMed:10747952).
Cellular Location Golgi apparatus membrane; Single- pass type II membrane protein
Tissue Location Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene catalyzes the transfer ofgalactose to lactosylceramide to form globotriaosylceramide, whichhas been identified as the P(k) antigen of the P blood groupsystem. The encoded protein, which is a type II membrane proteinfound in the Golgi, is also required for the synthesis of thebacterial verotoxins receptor.

References

Zumbrun, S.D., et al. Infect. Immun. 78(11):4488-4499(2010)Shin, I.S., et al. BMB Rep 42(5):310-314(2009)Lund, N., et al. Blood 113(20):4980-4991(2009)Okuda, T., et al. Glycobiology 18(12):1028-1035(2008)Hellberg, A., et al. BMC Genet. 6, 49 (2005) :

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$ 277.78
Cat# BP10116a
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