|Other Names||Lactosylceramide 4-alpha-galactosyltransferase, Alpha-1, 4-N-acetylglucosaminyltransferase, Alpha-1, 4-galactosyltransferase, Alpha4Gal-T1, CD77 synthase, Globotriaosylceramide synthase, Gb3 synthase, P1/Pk synthase, UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase, A4GALT, A14GALT, A4GALT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the transfer ofgalactose to lactosylceramide to form globotriaosylceramide, whichhas been identified as the P(k) antigen of the P blood groupsystem. The encoded protein, which is a type II membrane proteinfound in the Golgi, is also required for the synthesis of thebacterial verotoxins receptor.
Zumbrun, S.D., et al. Infect. Immun. 78(11):4488-4499(2010)Shin, I.S., et al. BMB Rep 42(5):310-314(2009)Lund, N., et al. Blood 113(20):4980-4991(2009)Okuda, T., et al. Glycobiology 18(12):1028-1035(2008)Hellberg, A., et al. BMC Genet. 6, 49 (2005) :
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