A4GALT Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NPC4 |
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Other Accession | NP_059132.1 |
Clone Names | 81006001 |
Gene ID | 53947 |
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Other Names | Lactosylceramide 4-alpha-galactosyltransferase, Alpha-1, 4-N-acetylglucosaminyltransferase, Alpha-1, 4-galactosyltransferase, Alpha4Gal-T1, CD77 synthase, Globotriaosylceramide synthase, Gb3 synthase, P1/Pk synthase, UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase, A4GALT, A14GALT, A4GALT1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | A4GALT |
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Synonyms | A14GALT, A4GALT1 |
Function | Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)) (PubMed:10748143). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143). Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P (PubMed:10747952). |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
Tissue Location | Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene catalyzes the transfer ofgalactose to lactosylceramide to form globotriaosylceramide, whichhas been identified as the P(k) antigen of the P blood groupsystem. The encoded protein, which is a type II membrane proteinfound in the Golgi, is also required for the synthesis of thebacterial verotoxins receptor.
References
Zumbrun, S.D., et al. Infect. Immun. 78(11):4488-4499(2010)Shin, I.S., et al. BMB Rep 42(5):310-314(2009)Lund, N., et al. Blood 113(20):4980-4991(2009)Okuda, T., et al. Glycobiology 18(12):1028-1035(2008)Hellberg, A., et al. BMC Genet. 6, 49 (2005) :
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