|Other Accession||NP_002304.3, NP_006711.3, NP_001003407.1, NP_001003408.1|
|Other Names||Actin-binding LIM protein 1, abLIM-1, Actin-binding LIM protein family member 1, Actin-binding double zinc finger protein, LIMAB1, Limatin, ABLIM1, ABLIM, KIAA0059, LIMAB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ABLIM, KIAA0059, LIMAB1|
|Function||May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton|
|Tissue Location||Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytoskeletal LIM protein that binds toactin filaments via a domain that is homologous to erythrocytedematin. LIM domains, found in over 60 proteins, play key roles inthe regulation of developmental pathways. LIM domains also functionas protein-binding interfaces, mediating specific protein-proteininteractions. The protein encoded by this gene could mediate suchinteractions between actin filaments and cytoplasmic targets.Alternatively spliced transcript variants encoding differentisoforms have been identified.
Feng, T., et al. Hum. Genet. 128(3):269-280(2010)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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