|Other Names||Lysine-specific demethylase hairless, 11411-, HR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1011a was selected from the N-term region of human HR1/2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle.|
|Tissue Location||Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases. Mutations in this gene have been documented in cases of autosomal recessive congenital alopecia and atrichia with papular lesions.
Henn, W., et al., J. Am. Acad. Dermatol. 47(4):519-523 (2002).Ahmad, W., et al., Genomics 56(2):141-148 (1999).Cichon, S., et al., Hum. Mol. Genet. 7(11):1671-1679 (1998).Nothen, M.M., et al., Am. J. Hum. Genet. 62(2):386-390 (1998).Ahmad, W., et al., Science 279(5351):720-724 (1998).
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