|Other Names||Protein BTG2, BTG family member 2, NGF-inducible anti-proliferative protein PC3, BTG2, PC3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of theBTG/Tob family. This family has structurally related proteins thatappear to have antiproliferative properties. This encoded proteinis involved in the regulation of the G1/S transition of the cellcycle.
Zhang, L., et al. Mol. Biol. Rep. 37(6):2579-2586(2010)Mollerstrom, E., et al. BMC Cancer 10, 296 (2010) :Park, T.J., et al. Exp. Cell Res. 315(18):3152-3162(2009)Liu, M., et al. Cell Res. 19(7):828-837(2009)Farioli-Vecchioli, S., et al. PLoS ONE 4 (12), E8339 (2009) :
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