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BRG1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P51532
Other Accession NP_003063.2, NP_001122316.1
Clone Names 81201002
Peptide ID 81201002
Additional Information
Gene ID 6597
Other Names Transcription activator BRG1, 364-, ATP-dependent helicase SMARCA4, BRG1-associated factor 190A, BAF190A, Mitotic growth and transcription activator, Protein BRG-1, Protein brahma homolog 1, SNF2-beta, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4, SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BAF190A, BRG1, SNF2B, SNF2L4
Function Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self- renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00549, ECO:0000269|PubMed:20418909}
Tissue Location Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level)
Research Areas
Citations (0)

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The protein encoded by this gene is a member of theSWI/SNF family of proteins and is similar to the brahma protein ofDrosophila. Members of this family have helicase and ATPaseactivities and are thought to regulate transcription of certaingenes by altering the chromatin structure around those genes. Theencoded protein is part of the large ATP-dependent chromatinremodeling complex SNF/SWI, which is required for transcriptionalactivation of genes normally repressed by chromatin. In addition,this protein can bind BRCA1, as well as regulate the expression ofthe tumorigenic protein CD44. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].


Bakshi, R., et al. J. Cell. Physiol. 225(2):569-576(2010)Alessio, N., et al. Oncogene 29(40):5452-5463(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Martinelli, N., et al. Blood (2010) In press :Hang, C.T., et al. Nature 466(7302):62-67(2010)

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$ 80.00
Cat# BP10122a
(40 western blots)
Availability: In Stock
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