|Other Accession||NP_001164191.1, NP_001164187.1, NP_001164186.1, NP_001164192.1, NP_001164185.1, NP_001164188|
|Other Names||Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAS, CASS1, CRKAS|
|Function||Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.|
|Cellular Location||Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.|
|Tissue Location||Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line|
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Provided below are standard protocols that you may find useful for product applications.
BCAR1, or CAS, is an Src (MIM 190090) family kinasesubstrate involved in various cellular events, including migration,survival, transformation, and invasion (Sawada et al., 2006 [PubMed17129785]).
Tai, C.J., et al. Exp. Cell Res. 316(17):2969-2981(2010)Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)Schuh, N.R., et al. J. Biol. Chem. 285(4):2309-2317(2010)Wendt, M.K., et al. J. Biol. Chem. 284(49):34145-34156(2009)Qian, X., et al. Cancer Cell 16(3):246-258(2009)
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