|Other Accession||NP_002916.1, NP_001005339.1|
|Other Names||Regulator of G-protein signaling 10, RGS10, RGS10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196).|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus|
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Regulator of G protein signaling (RGS) family members areregulatory molecules that act as GTPase activating proteins (GAPs)for G alpha subunits of heterotrimeric G proteins. RGS proteins areable to deactivate G protein subunits of the Gi alpha, Go alpha andGq alpha subtypes. They drive G proteins into their inactiveGDP-bound forms. Regulator of G protein signaling 10 belongs tothis family. All RGS proteins share a conserved 120-amino acidsequence termed the RGS domain. This protein associatesspecifically with the activated forms of the two related G-proteinsubunits, G-alphai3 and G-alphaz but fails to interact with thestructurally and functionally distinct G-alpha subunits. Regulatorof G protein signaling 10 protein is localized in the nucleus. Twotranscript variants encoding different isoforms have been found forthis gene.
Wang, J., et al. Carcinogenesis (2010) In press :Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Yang, S., et al. J. Cell. Sci. 120 (PT 19), 3362-3371 (2007) :Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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