|Other Names||C-C motif chemokine 21, 6Ckine, Beta-chemokine exodus-2, Secondary lymphoid-tissue chemokine, SLC, Small-inducible cytokine A21, CCL21, SCYA21|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.|
|Tissue Location||Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen|
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This gene is one of several CC cytokine genes clustered onthe p-arm of chromosome 9. Cytokines are a family of secretedproteins involved in immunoregulatory and inflammatory processes.The CC cytokines are proteins characterized by two adjacentcysteines. Similar to other chemokines the protein encoded by thisgene inhibits hemopoiesis and stimulates chemotaxis. This proteinis chemotactic in vitro for thymocytes and activated T cells, butnot for B cells, macrophages, or neutrophils. The cytokine encodedby this gene may also play a role in mediating homing oflymphocytes to secondary lymphoid organs. It is a high affinityfunctional ligand for chemokine receptor 7 (CCR7) that is expressedon T and B lymphocytes and a known receptor for another member ofthe cytokine family (small inducible cytokine A19). [provided byRefSeq].
Rey-Gallardo, A., et al. Glycobiology 20(9):1139-1146(2010)Cuesta-Mateos, C., et al. Exp. Hematol. 38(9):756-764(2010)Sundqvist, J., et al. Fertil. Steril. (2010) In press :Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)Farragher, T.M., et al. Arthritis Care Res (Hoboken) 62(5):676-682(2010)
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