|Other Accession||NP_659449.3, NP_859049.2|
|Other Names||Cyclin-Y, Cyc-Y, Cyclin box protein 1, Cyclin fold protein 1, cyclin-X, CCNY, C10orf9, CBCP1, CFP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C10orf9, CBCP1, CFP1|
|Function||Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Cyclins, such as CCNY, control cell division cycles andregulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li etal., 2009 [PubMed 18060517]).
Wang, K., et al. Hum. Mol. Genet. 19(10):2059-2067(2010)Xu, Y., et al. Oncol. Res. 18(8):359-364(2010)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Henckaerts, L., et al. Clin. Gastroenterol. Hepatol. 7(9):972-980(2009)Jiang, M., et al. FEBS Lett. 583(13):2171-2178(2009)
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