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CCNY Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8ND76 |
|---|---|
| Other Accession | NP_659449.3, NP_859049.2 |
| Clone Names | 90713032 |
| Gene ID | 219771 |
|---|---|
| Other Names | Cyclin-Y, Cyc-Y, Cyclin box protein 1, Cyclin fold protein 1, cyclin-X, CCNY, C10orf9, CBCP1, CFP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CCNY |
|---|---|
| Synonyms | C10orf9, CBCP1, CFP1 |
| Function | Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cyclins, such as CCNY, control cell division cycles andregulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li etal., 2009 [PubMed 18060517]).
References
Wang, K., et al. Hum. Mol. Genet. 19(10):2059-2067(2010)Xu, Y., et al. Oncol. Res. 18(8):359-364(2010)Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)Henckaerts, L., et al. Clin. Gastroenterol. Hepatol. 7(9):972-980(2009)Jiang, M., et al. FEBS Lett. 583(13):2171-2178(2009)
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