|Other Accession||NP_116563.1, NP_003814.1|
|Other Names||Tumor necrosis factor receptor superfamily member 6B, Decoy receptor 3, DcR3, Decoy receptor for Fas ligand, M68, TNFRSF6B, DCR3, TR6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.|
|Tissue Location||Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells|
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This gene belongs to the tumor necrosis factor receptorsuperfamily. The encoded protein is postulated to play a regulatoryrole in suppressing FasL- and LIGHT-mediated cell death. It acts asa decoy receptor that competes with death receptors for ligandbinding. Overexpression of this gene has been noted ingastrointestinal tract tumors, and it is located in a gene-richcluster on chromosome 20, with other potentially tumor-relatedgenes. Two transcript variants encoding the same isoform, butdiffering in the 5' UTR, have been observed for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Xiong, G., et al. Tumour Biol. 31(5):443-449(2010)Sung, H.Y., et al. Int. J. Radiat. Biol. 86(9):780-790(2010)Brunetti, G., et al. Ann. N. Y. Acad. Sci. 1192, 298-302 (2010) :Perdigones, N., et al. Arthritis Rheum. 62(3):705-710(2010)
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