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GPX4 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P36969
Other Accession NP_001034937.1, NP_001034936.1, NP_002076.2
Clone Names 90723049
Additional Information
Gene ID 2879
Other Names Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, PHGPx, Glutathione peroxidase 4, GPx-4, GSHPx-4, GPX4
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPX4 {ECO:0000303|PubMed:9705830, ECO:0000312|HGNC:HGNC:4556}
Function Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron- dependent accumulation of lipid reactive oxygen species (PubMed:24439385). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (PubMed:11115402). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down- regulator of the cellular 15-lipoxygenase pathway (By similarity). Can reduce fatty acid-derived hydroperoxides (PubMed:11115402, PubMed:36608588). Can also reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide (PubMed:36608588, PubMed:17630701).
Cellular Location [Isoform Mitochondrial]: Mitochondrion {ECO:0000250|UniProtKB:O70325}
Tissue Location Present primarily in testis. Expressed in platelets (at protein level) (PubMed:11115402).
Research Areas
Citations (0)
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Background

Glutathione peroxidase catalyzes the reduction of hydrogenperoxide, organic hydroperoxide, and lipid peroxides by reducedglutathione and functions in the protection of cells againstoxidative damage. Human plasma glutathione peroxidase has beenshown to be a selenium-containing enzyme and the UGA codon istranslated into a selenocysteine. Through alternative splicing andtranscription initiation, rat produces proteins that localize tothe nucleus, mitochondrion, and cytoplasm. In humans, experimentalevidence for alternative splicing exists; alternative transcriptioninitiation and the cleavage sites of the mitochondrial and nucleartransit peptides need to be experimentally verified. [provided byRefSeq].

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Abe, M., et al. BJU Int. (2010) In press :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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$ 277.78
Cat# BP10137c
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