|Other Accession||NP_001034937.1, NP_001034936.1, NP_002076.2|
|Other Names||Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, PHGPx, Glutathione peroxidase 4, GPx-4, GSHPx-4, GPX4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species, and by supporting T cell expansion.|
|Cellular Location||Isoform Mitochondrial: Mitochondrion.|
|Tissue Location||Present primarily in testis.|
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Provided below are standard protocols that you may find useful for product applications.
Glutathione peroxidase catalyzes the reduction of hydrogenperoxide, organic hydroperoxide, and lipid peroxides by reducedglutathione and functions in the protection of cells againstoxidative damage. Human plasma glutathione peroxidase has beenshown to be a selenium-containing enzyme and the UGA codon istranslated into a selenocysteine. Through alternative splicing andtranscription initiation, rat produces proteins that localize tothe nucleus, mitochondrion, and cytoplasm. In humans, experimentalevidence for alternative splicing exists; alternative transcriptioninitiation and the cleavage sites of the mitochondrial and nucleartransit peptides need to be experimentally verified. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Abe, M., et al. BJU Int. (2010) In press :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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