|Other Names||Helicase SKI2W, Ski2, 364-, Helicase-like protein, HLP, SKIV2L, DDX13, SKI2W, SKIV2, W|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DDX13, SKI2W, SKIV2, W|
|Function||Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).|
|Cellular Location||Nucleus. Cytoplasm|
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DEAD box proteins, characterized by the conserved motifAsp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alterationof RNA secondary structure such as translation initiation, nuclearand mitochondrial splicing, and ribosome and spliceosome assembly.Based on their distribution patterns, some members of this familyare believed to be involved in embryogenesis, spermatogenesis, andcellular growth and division. This gene encodes a DEAD box protein,which is a human homologue of yeast SKI2 and may be involved inantiviral activity by blocking translation of poly(A) deficientmRNAs. This gene is located in the class III region of the majorhistocompatibility complex.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Chen, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7401-7406(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
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