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PCDHGC3 Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UN70
Other Accession NP_115778.1, NP_002579.2, NP_115779.1
Clone Names 90625164
Additional Information
Gene ID 5098
Other Names Protocadherin gamma-C3, PCDH-gamma-C3, Protocadherin-2, Protocadherin-43, PC-43, PCDHGC3, PCDH2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCDHGC3
Synonyms PCDH2
Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Cellular Location Cell membrane; Single-pass type I membrane protein
Research Areas
Citations (0)
citation

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Background

This gene is a member of the protocadherin gamma genecluster, one of three related clusters tandemly linked onchromosome five. These gene clusters have an immunoglobulin-likeorganization, suggesting that a novel mechanism may be involved intheir regulation and expression. The gamma gene cluster includes 22genes divided into 3 subfamilies. Subfamily A contains 12 genes,subfamily B contains 7 genes and 2 pseudogenes, and the moredistantly related subfamily C contains 3 genes. The tandem array of22 large, variable region exons are followed by a constant region,containing 3 exons shared by all genes in the cluster. Eachvariable region exon encodes the extracellular region, whichincludes 6 cadherin ectodomains and a transmembrane region. Theconstant region exons encode the common cytoplasmic region. Theseneural cadherin-like cell adhesion proteins most likely play acritical role in the establishment and function of specificcell-cell connections in the brain. Alternative splicing has beendescribed for the gamma cluster genes.

References

Reiss, K., et al. J. Biol. Chem. 281(31):21735-21744(2006)Wu, Q., et al. Genome Res. 11(3):389-404(2001)Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000)

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$ 277.78
Cat# BP10141c
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