|Other Accession||NP_004099.2, NP_056652.1|
|Other Names||Ficolin-2, 37 kDa elastin-binding protein, Collagen/fibrinogen domain-containing protein 2, EBP-37, Ficolin-B, Ficolin-beta, Hucolin, L-ficolin, Serum lectin p35, FCN2, FCNL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the ficolin family ofproteins. This family is characterized by the presence of a leaderpeptide, a short N-terminal segment, followed by a collagen-likeregion, and a C-terminal fibrinogen-like domain. This gene ispredominantly expressed in the liver, and has been shown to havecarbohydrate binding and opsonic activities. Alternatively splicedtranscript variants encoding different isoforms have beenidentified.
de Rooij, B.J., et al. Hepatology 52(3):1100-1110(2010)Meijvis, S.C., et al. Nephrol. Dial. Transplant. (2010) In press :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Cedzynski, M., et al. Mol. Immunol. 47 (2-3), 415-419 (2009) :Liu, J., et al. Cell. Mol. Immunol. 6(4):235-244(2009)
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