FCN2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q15485 |
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Other Accession | NP_004099.2, NP_056652.1 |
Clone Names | 90805033 |
Gene ID | 2220 |
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Other Names | Ficolin-2, 37 kDa elastin-binding protein, Collagen/fibrinogen domain-containing protein 2, EBP-37, Ficolin-B, Ficolin-beta, Hucolin, L-ficolin, Serum lectin p35, FCN2, FCNL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FCN2 |
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Synonyms | FCNL |
Function | May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. |
Cellular Location | Secreted. |
Tissue Location | Expressed by the liver and secreted in plasma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene belongs to the ficolin family ofproteins. This family is characterized by the presence of a leaderpeptide, a short N-terminal segment, followed by a collagen-likeregion, and a C-terminal fibrinogen-like domain. This gene ispredominantly expressed in the liver, and has been shown to havecarbohydrate binding and opsonic activities. Alternatively splicedtranscript variants encoding different isoforms have beenidentified.
References
de Rooij, B.J., et al. Hepatology 52(3):1100-1110(2010)Meijvis, S.C., et al. Nephrol. Dial. Transplant. (2010) In press :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Cedzynski, M., et al. Mol. Immunol. 47 (2-3), 415-419 (2009) :Liu, J., et al. Cell. Mol. Immunol. 6(4):235-244(2009)
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