|Other Names||Protein phosphatase 1 regulatory subunit 14C, Kinase-enhanced PP1 inhibitor, PKC-potentiated PP1 inhibitory protein, Serologically defined breast cancer antigen NY-BR-81, PPP1R14C, KEPI|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of the PP1 regulatory subunit PPP1CA.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein|
|Tissue Location||Detected in breast cancer.|
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Provided below are standard protocols that you may find useful for product applications.
The degree of protein phosphorylation is regulated by abalance of protein kinase and phosphatase activities. Proteinphosphatase-1 (PP1; see MIM 176875) is a signal-transducingphosphatase that influences neuronal activity, protein synthesis,metabolism, muscle contraction, and cell division. PPP1R14C is aninhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied byOMIM].
Daskalow, K., et al. Anticancer Res. 30(5):1573-1578(2010)Scholz, S.W., et al. Ann. Neurol. 65(5):610-614(2009)Burgner, D., et al. PLoS Genet. 5 (1), E1000319 (2009) :Mungall, A.J., et al. Nature 425(6960):805-811(2003)Liu, Q.R., et al. J. Biol. Chem. 277(15):13312-13320(2002)
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