HINT2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BX68 |
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Other Accession | NP_115982.1 |
Clone Names | 90723186 |
Gene ID | 84681 |
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Other Names | Histidine triad nucleotide-binding protein 2, mitochondrial, HINT-2, 3---, HINT-3, HIT-17kDa, PKCI-1-related HIT protein, HINT2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HINT2 (HGNC:18344) |
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Function | Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367). Hydrolyzes adenosine 5'-O- p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638). Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367). May be involved in steroid biosynthesis (PubMed:18653718). May play a role in apoptosis (PubMed:16762638). |
Cellular Location | Mitochondrion |
Tissue Location | High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Histidine triad proteins, such as HINT2, are nucleotidehydrolases and transferases that act on the alpha-phosphate ofribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied byOMIM].
References
Lenglet, S., et al. Endocrinology 149(11):5461-5469(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Martin, J., et al. Gastroenterology 130(7):2179-2188(2006)Brenner, C. Biochemistry 41(29):9003-9014(2002)
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