|Other Accession||NP_057512.1, NP_001128658.1|
|Other Names||ABI gene family member 3, New molecule including SH3, Nesh, ABI3, NESH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.|
|Cellular Location||Cytoplasm. Note=Colocalizes with PAK2 at leading edge of cells|
|Tissue Location||Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of an adaptor protein family.Members of this family encode proteins containing a homeoboxhomology domain, proline rich region and Src-homology 3 (SH3)domain, and are components of the Abi/WAVE complex which regulatesRac-dependent actin polymerization. The encoded protein inhibitsectopic metastasis of tumor cells as well as cell migration. Thismay be accomplished through interaction with p21-activated kinase.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Hirao, N., et al. FEBS Lett. 580(27):6464-6470(2006)Ichigotani, Y., et al. Int. J. Mol. Med. 9(6):591-595(2002)Ichigotani, Y., et al. Cancer Res. 62(8):2215-2219(2002)Matsuda, S., et al. J. Hum. Genet. 46(8):483-486(2001)
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