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ABI3 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9P2A4
Other Accession NP_057512.1, NP_001128658.1
Clone Names 90909164
Peptide ID 90909164
Additional Information
Gene ID 51225
Other Names ABI gene family member 3, New molecule including SH3, Nesh, ABI3, NESH
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABI3
Synonyms NESH
Function May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.
Cellular Location Cytoplasm. Note=Colocalizes with PAK2 at leading edge of cells
Tissue Location Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle
Research Areas
Citations (0)

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Background

This gene encodes a member of an adaptor protein family.Members of this family encode proteins containing a homeoboxhomology domain, proline rich region and Src-homology 3 (SH3)domain, and are components of the Abi/WAVE complex which regulatesRac-dependent actin polymerization. The encoded protein inhibitsectopic metastasis of tumor cells as well as cell migration. Thismay be accomplished through interaction with p21-activated kinase.

References

Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Hirao, N., et al. FEBS Lett. 580(27):6464-6470(2006)Ichigotani, Y., et al. Int. J. Mol. Med. 9(6):591-595(2002)Ichigotani, Y., et al. Cancer Res. 62(8):2215-2219(2002)Matsuda, S., et al. J. Hum. Genet. 46(8):483-486(2001)

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$ 80.00
Cat# BP10155a
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