AADAT Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N5Z0 |
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Other Accession | NP_872603.1, NP_057312.1 |
Clone Names | 90819003 |
Gene ID | 51166 |
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Other Names | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, Alpha-aminoadipate aminotransferase, AadAT, Kynurenine aminotransferase II, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, Kynurenine--oxoglutarate transaminase II, AADAT, KAT2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AADAT (HGNC:17929) |
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Function | Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). |
Cellular Location | Mitochondrion. |
Tissue Location | Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is highly similar tomouse and rat kynurenine aminotransferase II. The rat protein is ahomodimer with two transaminase activities. One activity is thetransamination of alpha-aminoadipic acid, a final step in thesaccaropine pathway which is the major pathway for L-lysinecatabolism. The other activity involves the transamination ofkynurenine to produce kynurenine acid, the precursor of kynurenicacid which has neuroprotective properties. Two alternativetranscripts encoding the same isoform have been identified,however, additional alternative transcripts and isoforms may exist.
References
Han, Q., et al. Biosci. Rep. 28(4):205-215(2008)Rossi, F., et al. J. Biol. Chem. 283(6):3559-3566(2008)Han, Q., et al. J. Biol. Chem. 283(6):3567-3573(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Goh, D.L., et al. Mol. Genet. Metab. 76(3):172-180(2002)
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