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CHGA Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P10645 |
|---|---|
| Other Accession | NP_001266.1 |
| Clone Names | 90429070 |
| Gene ID | 1113 |
|---|---|
| Other Names | Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43, Pancreastatin, SS-18, WA-8, WE-14, LF-19, AL-11, GV-19, GR-44, ER-37, CHGA |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CHGA |
|---|---|
| Function | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. |
| Cellular Location | [Serpinin]: Secreted {ECO:0000250|UniProtKB:P26339}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P26339}. Note=Pyroglutaminated serpinin localizes to secretory vesicle. {ECO:0000250|UniProtKB:P26339} |
| Tissue Location | Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in urine (at protein level) (PubMed:37453717). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thechromogranin/secretogranin family of neuroendocrine secretoryproteins. It is found in secretory vesicles of neurons andendocrine cells. This gene product is a precursor to threebiologically active peptides; vasostatin, pancreastatin, andparastatin. These peptides act as autocrine or paracrine negativemodulators of the neuroendocrine system. Other peptides, includingchromostatin, beta-granin, WE-14 and GE-25, are also derived fromthe full-length protein. However, biological activities for thesemolecules have not been shown.
References
Ezzi, S.A., et al. J. Neurochem. 115(5):1102-1111(2010)Ma, Z., et al. J. Urol. 184(3):1182-1188(2010)Ramella, R., et al. J. Cell. Biochem. 110(1):70-79(2010)Dag, E., et al. Peptides 31(5):932-937(2010)Xie, Y.Q., et al. Zhonghua Xin Xue Guan Bing Za Zhi 37(12):1081-1084(2009)
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