|Other Accession||NP_996890.1, NP_002975.1, NP_001001435.1|
|Other Names||C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein, HC21, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta(1-69), Macrophage inflammatory protein 1-beta, MIP-1-beta, PAT 744, Protein H400, SIS-gamma, Small-inducible cytokine A4, T-cell activation protein 2, ACT-2, MIP-1-beta(3-69), CCL4, LAG1, MIP1B, SCYA4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||LAG1, MIP1B, SCYA4|
|Function||Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.|
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This gene is one of several cytokine genes clustered onthe q-arm of chromosome 17. Cytokines are a family of secretedproteins involved in immunoregulatory and inflammatory processes.This protein is similar to CCL4 which inhibits HIV entry by bindingto the cellular receptor CCR5. The copy number of this gene variesamong individuals; most individuals have 1-5 copies in the diploidgenome, although rare individuals do not contain this gene at all.The human genome reference assembly contains two copies of thisgene. This record represents the more centromeric gene. [providedby RefSeq].
Colobran, R., et al. Clin. Exp. Immunol. 162(1):41-52(2010)Lajoie, J., et al. J. Clin. Immunol. 30(1):90-98(2010)Colobran, R., et al. Genes Immun. 10(3):254-259(2009)Shostakovich-Koretskaya, L., et al. AIDS 23(6):679-688(2009)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
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