|Other Accession||NP_001161860.1, NP_001161861.1, NP_006070.2|
|Other Names||Cbp/p300-interacting transactivator 2, MSG-related protein 1, MRG-1, P35srj, CITED2, MRG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.|
|Cellular Location||Nucleus Note=Colocalizes with EP300 in dot-like structures|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene inhibits transactivationof HIF1A-induced genes by competing with binding of HIF1a top300-CH1. Mutations in this gene are a cause of cardiac septaldefects. Three transcript variants encoding the same protein havebeen found for this gene.
Yang, X.F., et al. Zhonghua Er Ke Za Zhi 48(4):293-296(2010)Sun, H.B. Ann. N. Y. Acad. Sci. 1192, 429-436 (2010) :Lau, W.M., et al. Int. J. Cancer 126(4):876-884(2010)van Agthoven, T., et al. Br. J. Cancer 101(11):1824-1832(2009)Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.