|Other Accession||NP_001161860.1, NP_001161861.1, NP_006070.2|
|Other Names||Cbp/p300-interacting transactivator 2, MSG-related protein 1, MRG-1, P35srj, CITED2, MRG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.|
|Cellular Location||Nucleus Note=Colocalizes with EP300 in dot-like structures|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene inhibits transactivationof HIF1A-induced genes by competing with binding of HIF1a top300-CH1. Mutations in this gene are a cause of cardiac septaldefects. Three transcript variants encoding the same protein havebeen found for this gene.
Yang, X.F., et al. Zhonghua Er Ke Za Zhi 48(4):293-296(2010)Sun, H.B. Ann. N. Y. Acad. Sci. 1192, 429-436 (2010) :Lau, W.M., et al. Int. J. Cancer 126(4):876-884(2010)van Agthoven, T., et al. Br. J. Cancer 101(11):1824-1832(2009)Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
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