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CLDN7 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O95471
Other Accession NP_001171951.1, NP_001298.3, NP_001171952.1
Clone Names 90909136
Peptide ID 90909136
Additional Information
Gene ID 1366
Other Names Claudin-7, CLDN-7, CLDN7, CEPTRL2, CPETRL2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLDN7
Function Plays a major role in tight junction-specific obliteration of the intercellular space.
Cellular Location Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction. Note=Co- localizes with EPCAM at the lateral cell membrane and tight junction
Tissue Location Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Research Areas
Citations (0)

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This gene encodes a member of the claudin family. Claudinsare integral membrane proteins and components of tight junctionstrands. Tight junction strands serve as a physical barrier toprevent solutes and water from passing freely through theparacellular space between epithelial or endothelial cell sheets,and also play critical roles in maintaining cell polarity andsignal transductions. Differential expression of this gene has beenobserved in different types of malignancies, including breastcancer, ovarian cancer, hepatocellular carcinomas, urinary tumors,prostate cancer, lung cancer, head and neck cancers, thyroidcarcinomas, etc.. Alternatively spliced transcript variantsencoding different isoforms have been found.


Kojima, F., et al. Oncol. Rep. 23(4):927-931(2010)Rendon-Huerta, E., et al. J Gastrointest Cancer 41(1):52-59(2010)Ouban, A., et al. Histol. Histopathol. 25(1):83-90(2010)Kaarteenaho, R., et al. Respir. Res. 11, 59 (2010) :Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009) :

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$ 80.00
Cat# BP10180b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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