|Other Accession||NP_001171951.1, NP_001298.3, NP_001171952.1|
|Other Names||Claudin-7, CLDN-7, CLDN7, CEPTRL2, CPETRL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space.|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Basolateral cell membrane. Cell junction, tight junction. Note=Co-localizes with EPCAM at the basolateral cell membrane and tight junction|
|Tissue Location||Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the claudin family. Claudinsare integral membrane proteins and components of tight junctionstrands. Tight junction strands serve as a physical barrier toprevent solutes and water from passing freely through theparacellular space between epithelial or endothelial cell sheets,and also play critical roles in maintaining cell polarity andsignal transductions. Differential expression of this gene has beenobserved in different types of malignancies, including breastcancer, ovarian cancer, hepatocellular carcinomas, urinary tumors,prostate cancer, lung cancer, head and neck cancers, thyroidcarcinomas, etc.. Alternatively spliced transcript variantsencoding different isoforms have been found.
Kojima, F., et al. Oncol. Rep. 23(4):927-931(2010)Rendon-Huerta, E., et al. J Gastrointest Cancer 41(1):52-59(2010)Ouban, A., et al. Histol. Histopathol. 25(1):83-90(2010)Kaarteenaho, R., et al. Respir. Res. 11, 59 (2010) :Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.