INPP4A Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96PE3 |
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Other Accession | NP_001127697.1, NP_001127696.1, NP_004018.1, NP_001557.1 |
Clone Names | 91023005 |
Gene ID | 3631 |
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Other Names | Type I inositol 3, 4-bisphosphate 4-phosphatase, Inositol polyphosphate 4-phosphatase type I, INPP4A |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | INPP4A |
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Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:20463662, PubMed:15716355). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:30071275) (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D- aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity). |
Cellular Location | Early endosome membrane. Recycling endosome membrane. Cell membrane. Nucleus Cytoplasm. Postsynaptic density {ECO:0000250|UniProtKB:Q9EPW0}. Note=Translocates to the plasma membrane upon EGF stimulation (PubMed:15716355). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (PubMed:30071275). |
Tissue Location | Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an Mg++ independent enzyme thathydrolyzes the 4-position phosphate from the inositol ring ofphosphatidylinositol 3,4-bisphosphate, inositol1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multipletranscript variants encoding distinct isoforms have been described.
References
Sasaki, J., et al. Nature 465(7297):497-501(2010)Rogers, A.J., et al. Am. J. Respir. Crit. Care Med. 179(12):1084-1090(2009)Kobayashi, S., et al. DNA Res. 15(4):253-265(2008)Sharma, M., et al. Am. J. Respir. Crit. Care Med. 177(7):712-719(2008)Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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