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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HD89 |
|---|---|
| Other Accession | NP_065148.1, NP_001180303.1 |
| Clone Names | 90713179 |
| Peptide ID | 90713179 |
| Gene ID | 56729 |
|---|---|
| Other Names | Resistin, Adipose tissue-specific secretory factor, ADSF, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, Cysteine-rich secreted protein FIZZ3, RETN, FIZZ3, HXCP1, RSTN |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RETN |
|---|---|
| Synonyms | FIZZ3, HXCP1, RSTN |
| Function | Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q99P87}. |
| Tissue Location | Expressed in white adipose tissue (at protein level) (PubMed:11201732). Widely expressed, with particularly strong expression in lung, bone marrow, breast and peripheral blood (PubMed:15248836). Expressed strongly in bone marrow and at lower levels in lung, but not detected in other tissues (PubMed:15064728). Isoform 2 is detected in adipose tissue, bone marrow, brain, lung, peripheral blood, placenta and thymus (PubMed:15248836). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the family defined by the mouseresistin-like genes. The characteristic feature of this family isthe C-terminal stretch of 10 cys residues with identical spacing.The mouse homolog of this protein is secreted by adipocytes, andmay be the hormone potentially linking obesity to type II diabetes.Alternatively spliced transcript variants encoding the same proteinhave been found for this gene.
References
Schaffler, A., et al. Am. J. Gastroenterol. 105(11):2474-2484(2010)Kim, S.K., et al. Arch. Med. Res. 41(4):269-274(2010)Tuttolomondo, A., et al. Cardiovasc Diabetol 9, 50 (2010) :Bik, W., et al. Neuro Endocrinol. Lett. 31(4):497-506(2010)Seol, H.J., et al. Hypertens Pregnancy 29(3):310-317(2010)
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