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FUS Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P35637 |
|---|---|
| Other Accession | NP_001164105.1, NP_004951.1 |
| Clone Names | 91009132 |
| Gene ID | 2521 |
|---|---|
| Other Names | RNA-binding protein FUS, 75 kDa DNA-pairing protein, Oncogene FUS, Oncogene TLS, POMp75, Translocated in liposarcoma protein, FUS, TLS |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FUS |
|---|---|
| Synonyms | TLS |
| Function | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre- mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). |
| Cellular Location | Nucleus Note=Displays a punctate pattern inside the nucleus and is excluded from nucleoli. |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a multifunctional protein component ofthe heterogeneous nuclear ribonucleoprotein (hnRNP) complex. ThehnRNP complex is involved in pre-mRNA splicing and the export offully processed mRNA to the cytoplasm. This protein belongs to theFET family of RNA-binding proteins which have been implicated incellular processes that include regulation of gene expression,maintenance of genomic integrity and mRNA/microRNA processing.Alternative splicing results in multiple transcript variants.Defects in this gene result in amyotrophic lateral sclerosis type6.
References
Kim, S.H., et al. J. Biol. Chem. 285(44):34097-34105(2010)Mackenzie, I.R., et al. Lancet Neurol 9(10):995-1007(2010)Yan, J., et al. Neurology 75(9):807-814(2010)Waibel, S., et al. Neurology 75(9):815-817(2010)Baumer, D., et al. Neurology 75(7):611-618(2010)
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