|Other Accession||NP_001164105.1, NP_004951.1|
|Other Names||RNA-binding protein FUS, 75 kDa DNA-pairing protein, Oncogene FUS, Oncogene TLS, POMp75, Translocated in liposarcoma protein, FUS, TLS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.|
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This gene encodes a multifunctional protein component ofthe heterogeneous nuclear ribonucleoprotein (hnRNP) complex. ThehnRNP complex is involved in pre-mRNA splicing and the export offully processed mRNA to the cytoplasm. This protein belongs to theFET family of RNA-binding proteins which have been implicated incellular processes that include regulation of gene expression,maintenance of genomic integrity and mRNA/microRNA processing.Alternative splicing results in multiple transcript variants.Defects in this gene result in amyotrophic lateral sclerosis type6.
Kim, S.H., et al. J. Biol. Chem. 285(44):34097-34105(2010)Mackenzie, I.R., et al. Lancet Neurol 9(10):995-1007(2010)Yan, J., et al. Neurology 75(9):807-814(2010)Waibel, S., et al. Neurology 75(9):815-817(2010)Baumer, D., et al. Neurology 75(7):611-618(2010)
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