|Other Names||Fibroblast growth factor 7, FGF-7, Heparin-binding growth factor 7, HBGF-7, Keratinocyte growth factor, FGF7, KGF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.|
|Tissue Location||Epithelial cell.|
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The protein encoded by this gene is a member of thefibroblast growth factor (FGF) family. FGF family members possessbroad mitogenic and cell survival activities, and are involved in avariety of biological processes, including embryonic development,cell growth, morphogenesis, tissue repair, tumor growth andinvasion. This protein is a potent epithelial cell-specific growthfactor, whose mitogenic activity is predominantly exhibited inkeratinocytes but not in fibroblasts and endothelial cells. Studiesof mouse and rat homologs of this gene implicated roles inmorphogenesis of epithelium, reepithelialization of wounds, hairdevelopment and early lung organogenesis.
Lin, C.B., et al. J. Dermatol. Sci. 59(2):91-97(2010)Bando, M., et al. Immunol. Cell Biol. 88(3):328-333(2010)Wang, X., et al. Biomaterials 31(9):2542-2548(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Aguilar, S., et al. PLoS ONE 4 (11), E8013 (2009) :
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