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TBCD Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9BTW9
Other Accession NP_005984.3
Clone Names 91023087
Peptide ID 91023087
Additional Information
Gene ID 6904
Other Names Tubulin-specific chaperone D, Beta-tubulin cofactor D, tfcD, SSD-1, Tubulin-folding cofactor D, TBCD, KIAA0988, SSD1, TFCD
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0988, SSD1, TFCD
Function Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374).
Cellular Location Cell junction, tight junction {ECO:0000250|UniProtKB:Q28205}. Lateral cell membrane {ECO:0000250|UniProtKB:Q28205}. Cytoplasm {ECO:0000250|UniProtKB:Q28205}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q28205}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized in cell-cell contacts. {ECO:0000250|UniProtKB:Q28205}
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Cofactor D is one of four proteins (cofactors A, D, E, andC) involved in the pathway leading to correctly folded beta-tubulinfrom folding intermediates. Cofactors A and D are believed to playa role in capturing and stabilizing beta-tubulin intermediates in aquasi-native confirmation. Cofactor E binds to the cofactorD/beta-tubulin complex; interaction with cofactor C then causes therelease of beta-tubulin polypeptides that are committed to thenative state.


Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Yoshida, T., et al. Int. J. Mol. Med. 24(4):539-547(2009)Cunningham, L.A., et al. J. Biol. Chem. 283(11):7155-7165(2008)Shultz, T., et al. FASEB J. 22(1):168-182(2008)

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$ 80.00
Cat# BP10195a
Availability: In Stock
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