|Other Names||Tubulin-specific chaperone D, Beta-tubulin cofactor D, tfcD, SSD-1, Tubulin-folding cofactor D, TBCD, KIAA0988, SSD1, TFCD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0988, SSD1, TFCD|
|Function||Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase- activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.|
|Cellular Location||Cell junction, tight junction. Lateral cell membrane. Cytoplasm. Cell junction, adherens junction. Note=Localized in cell- cell contacts.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Cofactor D is one of four proteins (cofactors A, D, E, andC) involved in the pathway leading to correctly folded beta-tubulinfrom folding intermediates. Cofactors A and D are believed to playa role in capturing and stabilizing beta-tubulin intermediates in aquasi-native confirmation. Cofactor E binds to the cofactorD/beta-tubulin complex; interaction with cofactor C then causes therelease of beta-tubulin polypeptides that are committed to thenative state.
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Yoshida, T., et al. Int. J. Mol. Med. 24(4):539-547(2009)Cunningham, L.A., et al. J. Biol. Chem. 283(11):7155-7165(2008)Shultz, T., et al. FASEB J. 22(1):168-182(2008)
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