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> home > Products > Peptides > Biological Process > Metabolic Process > DIS3 Antibody (Center) Blocking peptide
DIS3 Antibody (Center) Blocking peptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP10196c | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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DIS3 Antibody (Center) Blocking peptide - Product info | |
| Primary Accession | Q9Y2L1 |
| Other Accession | NP_001121698.1, NP_055768.3 |
| Clone Names | 91023089 |
| Calculated MW | 109003 Da |
DIS3 Antibody (Center) Blocking peptide - Additional info | |
| Gene ID 22894 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
DIS3 Antibody (Center) Blocking peptide - Protein Information | |
| Name DIS3 | |
| Synonyms KIAA1008, RRP44 | |
| Function Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities | |
| Cellular Location Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 | |
| Tissue Location Widely expressed. | |
DIS3 Antibody (Center) Blocking peptide - Related products
DIS3 Antibody (Center) Blocking peptide - Research Areas
PeptidesBiological ProcessMetabolic ProcessPrimary Metabolic ProcessCellular Metabolic ProcessCellular ProcessMacromolecule Metabolic ProcessCellular Macromolecule Metabolic ProcessCellular Component BiogenesisNitrogen Compound Metabolic ProcessCellular Nitrogen Compound Metabolic ProcessRNA Metabolic ProcessCellular CompartmentCytoplasmNucleolusNucleusIntracellular PartIntracellularMembrane-bounded OrganelleIntracellular Membrane-bounded OrganelleMembrane-enclosed LumenOrganelle LumenOrganelleIntracellular OrganelleIntracellular Organelle LumenOrganelle PartIntracellular Organelle PartNuclear LumenNuclear PartMacromolecular ComplexProtein ComplexMolecular FunctionCatalytic ActivityProtein BindingHydrolase Activity
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REFERENCES
Tomecki, R., et al. EMBO J. 29(14):2342-2357(2010)Andersen, J.S., et al. Nature 433(7021):77-83(2005)Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)Dunham, A., et al. Nature 428(6982):522-528(2004)Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)
