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GCC2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IWJ2 |
|---|---|
| Other Accession | NP_852118.1 |
| Clone Names | 91023097 |
| Gene ID | 9648 |
|---|---|
| Other Names | GRIP and coiled-coil domain-containing protein 2, 185 kDa Golgi coiled-coil protein, GCC185, CLL-associated antigen KW-11, CTCL tumor antigen se1-1, Ran-binding protein 2-like 4, RanBP2L4, Renal carcinoma antigen NY-REN-53, GCC2, KIAA0336, RANBP2L4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GCC2 |
|---|---|
| Synonyms | KIAA0336, RANBP2L4 |
| Function | Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2. |
| Cellular Location | Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein |
| Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a peripheral membraneprotein localized to the trans-Golgi network. It is sensitive tobrefeldin A. This encoded protein contains a GRIP domain which isthought to be used in targeting. Alternative splicing results inmultiple transcript variants.
References
Houghton, F.J., et al. Cell 138(4):787-794(2009)Hayes, G.L., et al. Mol. Biol. Cell 20(1):209-217(2009)Burguete, A.S., et al. Cell 132(2):286-298(2008)Efimov, A., et al. Dev. Cell 12(6):917-930(2007)Derby, M.C., et al. Traffic 8(6):758-773(2007)
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