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MED25 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q71SY5 |
|---|---|
| Other Accession | NP_112235.2 |
| Clone Names | 91102134 |
| Gene ID | 81857 |
|---|---|
| Other Names | Mediator of RNA polymerase II transcription subunit 25, Activator interaction domain-containing protein 1, Activator-recruited cofactor 92 kDa component, ARC92, Mediator complex subunit 25, p78, MED25, ACID1, ARC92, PTOV2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MED25 |
|---|---|
| Synonyms | ACID1, ARC92, PTOV2 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle and spleen. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a component of the transcriptionalcoactivator complex termed the Mediator complex. This complex isrequired for transcription of most RNA polymerase II-dependentgenes. The encoded protein plays a role in chromatin modificationand in preinitiation complex assembly. Mutations in this gene areassociated with Charcot-Marie-Tooth disease type 2B2. [provided byRefSeq].
References
Roupelieva, M., et al. J. Gen. Virol. 91 (PT 5), 1138-1149 (2010) :Leal, A., et al. Neurogenetics 10(4):275-287(2009)Lee, H.K., et al. EMBO J. 26(15):3545-3557(2007)Sato, S., et al. Mol. Cell 14(5):685-691(2004)Yang, F., et al. Proc. Natl. Acad. Sci. U.S.A. 101(8):2339-2344(2004)
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