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MAF1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H063 |
|---|---|
| Other Accession | NP_115648.2 |
| Clone Names | 91102256 |
| Gene ID | 84232 |
|---|---|
| Other Names | Repressor of RNA polymerase III transcription MAF1 homolog, MAF1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MAF1 |
|---|---|
| Function | Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:20887893, PubMed:17505538). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II- dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). |
| Cellular Location | Nucleus. Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is similar to Maf1, aSaccharomyces cerevisiae protein highly conserved in eukaryoticcells. Yeast Maf1 is a negative effector of RNA polymerase III (PolIII). It responds to changes in the cellular environment andrepresses pol III transcription. Biochemical studies identified theinitiation factor TFIIIB as a target for Maf1-dependent repression.
References
Kantidakis, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(26):11823-11828(2010)Shor, B., et al. J. Biol. Chem. 285(20):15380-15392(2010)Johnson, S.S., et al. Mol. Cell 26(3):367-379(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Rollins, J., et al. Int. J. Biol. Sci. 3(5):292-302(2007)
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