|Other Names||Repressor of RNA polymerase III transcription MAF1 homolog, MAF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|
|Cellular Location||Nucleus. Cytoplasm.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is similar to Maf1, aSaccharomyces cerevisiae protein highly conserved in eukaryoticcells. Yeast Maf1 is a negative effector of RNA polymerase III (PolIII). It responds to changes in the cellular environment andrepresses pol III transcription. Biochemical studies identified theinitiation factor TFIIIB as a target for Maf1-dependent repression.
Kantidakis, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(26):11823-11828(2010)Shor, B., et al. J. Biol. Chem. 285(20):15380-15392(2010)Johnson, S.S., et al. Mol. Cell 26(3):367-379(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Rollins, J., et al. Int. J. Biol. Sci. 3(5):292-302(2007)
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