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FPRL1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P25090 |
|---|---|
| Other Accession | NP_001005738.1, NP_001453.1 |
| Clone Names | 90625034 |
| Gene ID | 2358 |
|---|---|
| Other Names | N-formyl peptide receptor 2, FMLP-related receptor I, FMLP-R-I, Formyl peptide receptor-like 1, HM63, Lipoxin A4 receptor, LXA4 receptor, RFP, FPR2, FPRH1, FPRL1, LXA4R |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FPR2 |
|---|---|
| Synonyms | FPRH1, FPRL1, LXA4R |
| Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti- inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL- induced osteoclast differentiation (By similarity). Acts as a receptor for humanin (PubMed:15465011). |
| Cellular Location | Cell membrane; Multi-pass membrane protein Note=Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized (PubMed:11689470). Also internalized in the presence of humanin (PubMed:15465011). |
| Tissue Location | Detected in lung, bone marrow, neutrophils, spleen and testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Yang, E.M., et al. Ann. Allergy Asthma Immunol. 105(1):96-97(2010)Kretschmer, D., et al. Cell Host Microbe 7(6):463-473(2010)Lee, H.Y., et al. Exp. Mol. Med. 42(4):302-309(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Kim, S.D., et al. J. Immunol. 183(9):5511-5517(2009)
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