|Other Names||Fibroblast growth factor 9, FGF-9, Glia-activating factor, GAF, Heparin-binding growth factor 9, HBGF-9, FGF9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.|
|Tissue Location||Glial cells.|
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The protein encoded by this gene is a member of thefibroblast growth factor (FGF) family. FGF family members possessbroad mitogenic and cell survival activities, and are involved in avariety of biological processes, including embryonic development,cell growth, morphogenesis, tissue repair, tumor growth andinvasion. This protein was isolated as a secreted factor thatexhibits a growth-stimulating effect on cultured glial cells. Innervous system, this protein is produced mainly by neurons and maybe important for glial cell development. Expression of the mousehomolog of this gene was found to be dependent on Sonic hedgehog(Shh) signaling. Mice lacking the homolog gene displayed amale-to-female sex reversal phenotype, which suggested a role intesticular embryogenesis.
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Kalinina, J., et al. Mol. Cell. Biol. 29(17):4663-4678(2009)Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)Wu, X.L., et al. Am. J. Hum. Genet. 85(1):53-63(2009)
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