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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   DNMT2 (TRDMT1) Antibody (Center A198) Blocking peptide   

DNMT2 (TRDMT1) Antibody (Center A198) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O14717
Clone Names 70411225
Additional Information
Gene ID 1787
Other Names tRNA (cytosine(38)-C(5))-methyltransferase, DNA (cytosine-5)-methyltransferase-like protein 2, Dnmt2, DNA methyltransferase homolog HsaIIP, DNA MTase homolog HsaIIP, MHsaIIP, PuMet, TRDMT1, DNMT2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1021d was selected from the DNMT2 region of human TRDMT1 (DNMT2). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DNMT2
Function Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
Cellular Location Nucleus.
Tissue Location Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes
Research Areas
Citations (0)

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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. TRDMT1 shows similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome.


Hermann, A., et al., J. Biol. Chem. 278(34):31717-31721 (2003).Franchina, M., et al., Int. J. Biochem. Cell Biol. 33(11):1104-1115 (2001).Dong, A., et al., Nucleic Acids Res. 29(2):439-448 (2001).Yoder, J.A., et al., Hum. Mol. Genet. 7(2):279-284 (1998).Van den Wyngaert, I., et al., FEBS Lett. 426(2):283-289 (1998).

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$ 80.00
Cat# BP1021d
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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