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IKZF1 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q13422
Other Accession NP_006051.1
Clone Names 91013161
Peptide ID 91013161
Additional Information
Gene ID 10320
Other Names DNA-binding protein Ikaros, Ikaros family zinc finger protein 1, Lymphoid transcription factor LyF-1, IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IKZF1
Synonyms IK1, IKAROS, LYF1, ZNFN1A1
Function Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta- globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).
Cellular Location Nucleus. Note=In resting lymphocytes, distributed diffusely throughout the nucleus Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events Isoform Ik6: Cytoplasm.
Tissue Location Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.
Research Areas
Citations (0)

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He, C.F., et al. Lupus 19(10):1181-1186(2010)Yang, L., et al. Oncol. Rep. 24(2):571-577(2010)Jager, R., et al. Leukemia 24(7):1290-1298(2010)Kuiper, R.P., et al. Leukemia 24(7):1258-1264(2010)Matulic, M., et al. Coll Antropol 34(1):59-62(2010)

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$ 80.00
Cat# BP10222b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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