MLXIP Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9HAP2 |
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Other Accession | NP_055753.3 |
Clone Names | 91113256 |
Gene ID | 22877 |
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Other Names | MLX-interacting protein, Class E basic helix-loop-helix protein 36, bHLHe36, Transcriptional activator MondoA, MLXIP (HGNC:17055) |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MLXIP (HGNC:17055) |
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Function | Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. |
Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Mitochondrion outer membrane Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875} |
Tissue Location | Widely expressed in adult tissues. Most abundant in skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MONDOA forms heterodimers with MLX (MIM 602976) that canbind to and activate transcription from CACGTG E boxes (Billin etal., 2000 [PubMed 11073985]).
References
Peterson, C.W., et al. Mol. Cell. Biol. 30(12):2887-2895(2010)Kaadige, M.R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(35):14878-14883(2009)Stoltzman, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 105(19):6912-6917(2008)Sans, C.L., et al. Mol. Cell. Biol. 26(13):4863-4871(2006)Bornhauser, B.C., et al. J. Biol. Chem. 278(37):35412-35420(2003)
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