|Other Accession||NP_001762.2, NP_001172028.1, NP_001172030.1, NP_001172029.1|
|Other Names||B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14, CD22, CD22, SIGLEC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Uckun, F.M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(39):16852-16857(2010)Ramya, T.N., et al. Mol. Cell Proteomics 9(6):1339-1351(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)El-Sayed, Z.A., et al. Egypt J Immunol 16(1):27-38(2009)
If you have any additional inquiries please email technical services at email@example.com.