|Other Names||FH1/FH2 domain-containing protein 3, Formactin-2, Formin homolog overexpressed in spleen 2, hFHOS2, FHOD3, FHOS2, KIAA1695|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.|
|Cellular Location||Cytoplasm, cytoskeleton. Note=Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining.|
|Tissue Location||Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Proteins that contain formin (FMN1; MIM 136535) homology(FH) domains, such as FHOD3, play a role in regulation of the actincytoskeleton (Kanaya et al., 2005 [PubMed 15966898]).[supplied byOMIM].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Adkins, D.E., et al. Mol. Psychiatry (2010) In press :Taniguchi, K., et al. J. Biol. Chem. 284(43):29873-29881(2009)French, D., et al. Blood 113(19):4512-4520(2009)Kanaya, H., et al. Genes Cells 10(7):665-678(2005)
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